Publications by authors named "M J Gosalbes"
Background: Despite effective antiretroviral therapy, people with HIV (PWH) experience persistent systemic inflammation and increased morbidity and mortality. Modulating the gut microbiome through fecal microbiota transplantation (FMT) represents a novel therapeutic strategy. We aimed to evaluate proteomic changes in inflammatory pathways following repeated, low-dose FMT versus placebo.
View Article and Find Full Text PDFBackground: The relationship of microbiota composition dynamics and the progression of subclinical atherosclerosis in people with HIV (PWH) remains unknown.
Methods: 96-week, prospective, longitudinal study in virologically-suppressed PWH. Carotid intima-media thickness (cIMT) measurements and stool samples were obtained at baseline, 48-week and 96-week visits.
Article Synopsis
- A digestion-fermentation model and 16S rRNA gene sequencing were used to analyze how different foods from Mediterranean and Western diets affect gut microbiota.
- Animal and plant-derived foods influenced the levels of certain bacteria, with fats from animal sources and certain dairy products increasing beneficial bacteria, while some foods also raised the levels of harmful bacteria linked to diseases.
- Cooking methods like frying and boiling significantly impacted the gut microbiota, with responses varying by food type; this suggests that personalized diets need to consider individual reactions to different cooking methods and foods.
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View Article and Find Full Text PDFAims: Vaccine response is poor among children living with HIV. The gut microbiota has been identified as a potential target to improve vaccine immunogenicity, but data are scarce in the context of HIV infection.
Methods: Pilot, double-blind, randomized placebo-controlled trial in which 24 HIV-infected children were randomized to receive a mixture of symbiotics, omega-3/6 fatty acids, and amino acids or placebo for 4 weeks, each in combination with ART, and were then immunized against influenza.