Publications by authors named "M J Germain"
Mitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is modulated by mitochondrial fission and fusion, which are required to properly balance metabolic functions, transfer material between mitochondria, and remove defective mitochondria. Mitochondrial fission occurs at mitochondria-endoplasmic reticulum (ER) contact sites, and requires the formation of actin filaments that drive mitochondrial constriction and the recruitment of the fission protein DRP1.
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- Non-melanoma skin cancers (NMSCs) are the most common type of cancer in the U.S., and image-guided superficial radiation therapy (IGSRT) effectively treats them, but the influence of patient comorbidities and socioeconomic status (SES) on treatment outcomes has been under-researched.
- A large retrospective study analyzed nearly 20,000 NMSC lesions to determine how SES and comorbidity levels (using ADI and CCI metrics) affected recurrence rates after IGSRT, finding minimal differences in outcomes for both factors at 2, 4, and 6 years.
- Results showed that neither SES nor comorbidity burden significantly impacted recurrence rates, suggesting that I
Venous thromboembolism (VT) is a frequent (annual incidence of 1 to 2 per 1,000) and potentially life-threatening (case-fatality rate up to 10%) disease. VT is associated with serious short-term and long-term complications including a recurrence rate of approximately 20% within five years. Anticoagulant therapy, the mainstay of VT treatment, drastically reduces the risk of early VT recurrence, but it exposes patients to a substantial risk of bleeding.
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- Factor V (FV) is crucial for the blood coagulation process, and its plasma levels are linked to various health issues like blood clots and diabetes.
- The researchers used a specific statistical method called the Brown-Forsythe methodology to analyze genetic factors affecting FV levels in 4505 individuals from four different studies.
- They identified a significant genetic variant (rs75463553) associated with the variability in FV plasma levels, highlighting the interaction between neutrophil-related genes and FV biology.
Artificial Intelligence (AI) and Human Caring: Challenges and Possibilities.
J Transcult Nurs
November 2024