Publications by authors named "M J Gawel"

Article Synopsis
  • - The report introduces a new high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method to measure a specific compound, HPPTCA, related to cysteine and vitamin B6, using 4-deoxypyridoxine as an internal standard.
  • - Sample preparation includes extracting HPPTCA from plasma proteins with acetonitrile, followed by ultrafiltration and dilution before analysis; the separation process takes 6 minutes at a controlled temperature with a precise gradient elution.
  • - The assay demonstrated linearity in measuring HPPTCA levels in plasma with a detection limit of 0.25 µmol/L, successfully confirming HPPTCA presence in samples from healthy donors with concentrations between
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Background/objectives: Intimate partner violence (IPV) and child physical abuse frequently co-occur, yet IPV-exposed children are not routinely evaluated for abuse. Furthermore, IPV survivors often seek care for their children but not for themselves, making pediatric visits an opportunity to address IPV. We developed a trauma- and violence-informed care (TVIC)-based model that 1) evaluated IPV-exposed children and 2) linked survivor-caregivers to an IPV advocate.

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We report biochemical and structural studies on inhibiting bacterial -adenosyl-L-homocysteine hydrolase by transition metal cations. Our results revealed diverse molecular mechanisms of enzyme inactivation. Depending on the cation, the mechanism is based on arresting the enzyme in its closed, inactive conformation, disulfide bond formation within the active site or oxidation of the intermediate form of a cofactor.

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Background: The upper limb is crucial for functioning in everyday life, thus comprehensive assessment is crucial for physically active people to monitor the effect of exercise and prevent injuries. The aim of this study was to analyse the relationship between upper limb function, shoulder mobility, and posture in individuals who participate in recreational strength training.

Methods: Thirty-four subjects who engaged in strength training of the upper limbs were divided into two groups: Group 1 (exercise < 3 years) and Group 2 (exercise ≥ 3 years).

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Background: Obtaining accurate information is critical for youth's sexual and reproductive health (SRH). Youth not in foster care often learn about SRH from their biological parents. Separated from their biological parents, youth in care depend on healthcare providers and caregivers for SRH information.

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