Publications by authors named "M J Fragoso-Vazquez"
There is an urgent need to develop new antifungals due to the increasing prevalence of multidrug-resistant fungal infections and the recent emergence of COVID-19-associated candidiasis. A good study model for evaluating new antifungal compounds is , an opportunistic fungal pathogen with intrinsic resistance to azoles (the most common clinical drugs for treating fungal infections). The aim of the current contribution was to conduct tests of antifungal metabolites produced by the bacteria Q, identify their molecular structures, and utilize several techniques to provide evidence of their therapeutic target.
View Article and Find Full Text PDFOur work group designed and synthesized a promissory compound N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA). The HO-AAVPA is a HDAC1 inhibitor and antiproliferative in cancer cell lines. However, HO-AAVPA is poor water solubility and enzymatically metabolized.
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- Sargassum is a marine organism that can overpopulate and harm the environment, but it also holds potential as a source of bioactive compounds for cancer treatment.
- The study aimed to test different extracts of sargassum for their effects on cancer cells and toxicity to a model organism, Artemia salina, using metabolomic analysis to identify active compounds.
- Results indicated that the ethanolic extract was most effective against breast cancer cell lines (MCF-7 and MDA-MB-231) while showing some antiproliferative effects on NIH3T3 cells, suggesting the need for further exploration of its beneficial compounds.
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- Generation 4 polyamidoamine dendrimer (G4-PAMAM) has a unique globular structure that leads to various biological effects, including cytotoxicity due to its positive charges, which can be more pronounced in cancer cells with high negative charges.
- The study utilized advanced techniques like UHPLC-QTOF-MS/MS to analyze G4-PAMAM's chemical structure and understand its charge distribution.
- G4-PAMAM demonstrated significant antiproliferative effects on HMC-1 and K-562 cancer cell lines over 24, 48, and 72 hours, and was found to localize in the cytoplasm and nucleus of these cells.
Glioblastoma multiforme (GBM) is account for 70% of all primary malignancies of the central nervous system. The median survival of human patients after treatment is around 15 months. There are several biological targets which have been reported that can be pursued using ligands with varied structures to treat this disease.
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