Mutational Landscape of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Association with Immune Checkpoint Inhibitor Outcome.

Purpose: Understanding the mutational landscape of recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is important in identifying biomarkers to determine which patients may benefit from immune checkpoint inhibitors (ICIs).

Patients And Methods: The HAWK (NCT02207530), CONDOR (NCT02319044), and EAGLE (NCT02369874) studies evaluated R/M HNSCC treatment with durvalumab or durvalumab-tremelimumab. Tumor tissue samples pooled from HAWK/CONDOR (n=153) and plasma cell-free DNA samples from EAGLE (n=285) were analyzed to identify somatic alterations and association with survival.

Role of interleukin-10 and interferon-β as predictive factors of severity in a paediatric population with dengue.

The febrile illness caused by dengue is a global public health problem whose incidence is increasing. This infection can range from mild fever to severe illness with plasma leakage and shock; therefore, biomarkers of severity are urgently needed to elucidate the pathological mechanism of the disease. To explore the levels of interleukin (IL)-10 and interferon (IFN)-β in children with dengue to identify these proteins as biomarkers of severity.

ROXSI: Robust Cross-Sequence Semantic Interaction for Brain Tumor Segmentation on Multi-Sequence MR Images.

Deep learning-based brain tumor segmentation on multi-sequence magnetic resonance imaging (MRI) has gained widespread attention due to its great potential in supporting brain disease diagnosis. Although, compared to single-sequence images, more information is available from multi-sequence MR images, noise and artifacts on any given MR sequence can result in significant performance degradations. As in clinical routine, it is not always possible to maintain high imaging quality across all MR sequences (e.

Distinct phytoplankton size classes respond differently to biotic and abiotic factors.

The interplay between abiotic (resource supply, temperature) and biotic (grazing) factors determines growth and loss processes in phytoplankton through resource competition and trophic interactions, which are mediated by morphological traits like size. Here, we study the relative importance of grazers, water physics, and chemistry on the daily net accumulation rates (ARs) of individual phytoplankton from natural communities, grouped into six size classes from circa 10 to 500 μm. Using a Random Forest modelling approach and 4 years of daily data from a lake, we find that water temperature is generally a pivotal control of all phytoplankton ARs.

Charge combinations and conviction rates among alcohol-influenced drivers involved in motor vehicle crashes in Iowa.

Introduction: Alcohol impairment is a major contributor to road traffic crashes and has increased across the United States in recent years. In 2022, over 13,000 people were killed in drunk driving crashes. Enforcement of impaired driving laws is an essential strategy to reduce alcohol-impaired driving and subsequent crashes.