Clinical Consultation in the Workplace: Are There Implications for Response Attitudes?

The clinical-organizational context (where clinical psychology services are provided in the individuals' professional setting) has still been insufficiently approached in research, namely the influence it may have on the response attitudes of individuals undergoing psychological assessment. Our main goal is to find out if, when psychological assessment occurs in the workplace context, patients being assessed present specific response bias that may have implications for the clinical results and correlative decisions. Five hundred and ten adult participants grouped in two samples of ambulatory patients - Clinical-Organizational Sample (COS = 238) and Clinical Sample (CS = 272) - were assessed with the Minnesota Multiphasic Personality Inventory-2-RF validity and substantive scales.

Variability of excessive daytime sleepiness and cataplexy according to seasonality: A study in central disorders of hypersomnolence.

Seasonality of excessive daytime sleepiness has been proposed, yet no research has specifically investigated its impact on daytime sleepiness and cataplexy in central disorders of hypersomnolence. This study examined seasonal variations in daytime sleepiness and cataplexy in narcolepsy type 1, narcolepsy type 2 and idiopathic hypersomnia. Patients included in the study were on stable pharmacological treatment, and participated in sleep medicine interviews to assess diurnal sleepiness and daytime napping and completed the Epworth Sleepiness Scale to assess excessive daytime sleepiness (Epworth Sleepiness Scale ≥ 10).

Study of the Anti-MYC Potential of Lanostane-Type Triterpenes.

One of the most investigated molecular targets for anticancer therapy is the proto-oncogene , which is amplified and thus overexpressed in many types of cancer. Due to its structural characteristics, developing inhibitors for the target has proven to be challenging. In this study, the anti-MYC potential of lanostane-type triterpenes was investigated for the first time, using computational approaches that involved ensemble docking, prediction of structural properties and pharmacokinetic parameters, molecular dynamics (MD), and binding energy calculation using the molecular mechanics-generalized born surface area (MM-GBSA) method.

Clinical validation of the excessive sedentary behavior nursing diagnosis in university students.

Purpose: To evaluate the accuracy of clinical indicators and etiological factors associated with the nursing diagnosis of excessive sedentary behavior among university students.

Method: This study employed a cross-sectional diagnostic accuracy design. The sample comprised 108 students from a Brazilian public university.