Early detection and prediction of cardiotoxicity after radiation therapy for breast cancer: the BACCARAT prospective cohort study.

Background: Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from breast cancer but it can lead to secondary effects due to the presence of neighboring cardiac normal tissues within the irradiation field. Breast RT has been shown to be associated with long-term increased risk of heart failure, coronary artery disease, myocardial infarction and finally cardiovascular death more than 10 years after RT. However, there is still a lack of knowledge for early cardiotoxicity induced by breast RT that can appear long before the onset of clinically significant cardiac events.

[Transposition of a tube and transposition of an ovary in the treatment of sterility].

The transposition of an ovary or of a tube is a simple procedure and it is valuable in certain kinds of tubal pathology. In the four cases here presented this technique allowed three pregnancies to occur. It can however only be used in certain types of lesions.

[Obstetric and neonatal consequences of urinary infection during pregnancy].

In this article, the authors study the real obstetrical and neonatal effects of urinary infection in pregnant women. Basing themselves on 225 cases of gravidic urinary infection, the authors discuss asymptomatic bacteriuria, the need of early diagnosis in risk patients, and the use of regular post-treatment monitoring, in view of the fact that, even when well-treated, this complaint is apt to recur.

[Idiopathic thrombopenic purpura and pregnancy].

Idiopathic thrombocytopenic purpura occurring in pregnancy has a risk for the fetus of severe thrombocytopenia. The handling of these cases obstetrically is controversial. Our experience and that derived from reading the literature suggests that counting the number of maternal platelets does not reflect on the risk for the fetus and the neonate.

[Digestive complications of radiotherapy of gynecologic cancers: therapeutic possibilities].

It appears that there are a certain number of complications in the digestive tract that still occur in spite of improvements in techniques of irradiation therapy. They may only appear a few months or even a few years after the treatment, and sometimes they only appear when the initial growth is considered to have been cured. The clinical picture is dominated by the appearance of fistulae, of adhesions and of stenoses which give rise to sub-acute or sometimes acute obstructions.