Publications by authors named "M J Domanico"
Regional responses to inhaled toxicants are essential to understand the pathogenesis of lung disease under exposure to air pollution. We evaluated the effect of combined allergen sensitization and ozone exposure on eliciting spatial differences in lipid distribution in the mouse lung that may contribute to ozone-induced exacerbations in asthma. Lung lobes from male and female BALB/c mice were cryosectioned and acquired by high resolution mass spectrometry imaging (MSI).
View Article and Find Full Text PDFUnlabelled: The multi-target stool DNA (mt-sDNA) test screens for colorectal cancer by analyzing DNA methylation/mutation and hemoglobin markers to algorithmically derive a qualitative result. A new panel of highly discriminant candidate methylated DNA markers (MDM) was recently developed. Performance of the novel MDM panel, with hemoglobin, was evaluated in a simulated screening population using archived stool samples weighted to early-stage colorectal cancer and prospectively collected advanced precancerous lesions (APL).
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- - European brown hare syndrome (EBHS) is a deadly viral disease affecting mainly European brown hares, caused by the EBHS virus (EBHSV), which poses a significant threat to populations such as the vulnerable Italian hare.
- - This study investigated two free-ranging Italian hares found dead in Central Italy, identifying EBHS through harmful lesions, viral detection in their livers, and genetic analysis confirming the presence of EBHSV.
- - The EBHSV strain found in these hares had a close genetic match to a strain from Germany in 2019, highlighting the spread of EBHS and emphasizing the need for conservation efforts for vulnerable species like the Italian hare in protected areas.
Asthma is a common chronic respiratory disease exacerbated by multiple environmental factors. Acute ozone exposure has previously been implicated in airway inflammation, airway hyperreactivity, and other characteristics of asthma, which may be attributable to altered sphingolipid metabolism. This study tested the hypothesis that acute ozone exposure alters sphingolipid metabolism within the lung, which contributes to exacerbations in characteristics of asthma in allergen-sensitized mice.
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- 2D engineered nanomaterials are extensively utilized in products due to their distinct properties, but they can be aerosolized during manufacturing and might negatively interact with biological tissues like the lungs and eyes.
- Eight different 2D nanomaterials, including various forms of graphene and hexagonal boron nitride, were tested for their toxic effects on epithelial cells from murine and human sources.
- Hexagonal boron nitride demonstrated cytotoxicity across multiple cell types but did not inhibit wound healing at lower, non-toxic concentrations, highlighting the need for cautious use of nanomaterials due to varying toxicity depending on cell type.