The focus of this study was the development of a second generation of fiber lasers internally cooled by anti-Stokes fluorescence. The laser consisted of a length of a single-mode fiber spliced to fiber Bragg gratings to form the optical resonator. The fiber was single-moded at the pump (1040 nm) and signal (1064 nm) wavelengths.
View Article and Find Full Text PDFAptamers are a promising class of affinity reagents because signal transduction mechanisms can be built into the reagent, so that they can directly produce a physically measurable output signal upon target binding. However, endowing the signal transduction functionality into an aptamer remains a trial-and-error process that can compromise its affinity or specificity and typically requires knowledge of the ligand binding domain or its structure. In this work, a design architecture that can convert an existing aptamer into a "reversible aptamer switch" whose kinetic and thermodynamic properties can be tuned without a priori knowledge of the ligand binding domain or its structure is described.
View Article and Find Full Text PDFThis special issue contains a collection of papers on optical fiber sensors that were originally presented and published in a more succinct form in conjunction with the 27th International Conference on Optical Fiber Sensors (OFS) held in Alexandria, Virginia, United States, from 29th August to 2nd September, 2022.
View Article and Find Full Text PDFThe first observation of cooling by anti-Stokes pumping in nanoparticle-doped silica fibers is reported. Four Yb-doped fibers fabricated using conventional modified chemical vapor deposition (MCVD) techniques were evaluated, namely, an aluminosilicate fiber and three fibers in which the Yb ions were encapsulated in CaF, SrF, or BaF nanoparticles. The nanoparticles, which oxidize during preform processing, provide a modified chemical environment for the Yb ions that is beneficial to cooling.
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