Publications by authors named "M J Daemen"
Background: Huntington's disease (HD) poses significant challenges for both affected individuals and their informal caregivers. With the progression of HD, caregivers frequently prioritize caring for the person with HD over their own well-being. 'Partner in Balance' (PiB) is an 8-week online self-management program guided by a personal coach, developed to help caregivers of people with HD cope with challenging situations and develop skills to increase resilience and prevent overburdening.
View Article and Find Full Text PDFBackground And Purpose: Intracranial atherosclerosis is one of the most common causes of ischaemic stroke. However, there is a substantial knowledge gap on the development of intracranial atherosclerosis. Intracranial arteries are characterized by an upregulation of tight junctions between endothelial cells, which control endothelial permeability.
View Article and Find Full Text PDFAim: To investigate the experiences of people with Parkinson's disease in coping with and adapting to their disease and to identify considerations for a tailored self-management support program.
Design: A descriptive phenomenological focus group study.
Methods: Five semi-structured focus groups were conducted between April 2023 and June 2023 in the Netherlands, with 12 people with Parkinson's disease.
Article Synopsis
- The study explores the ecological momentary intervention (EMI) called SELFIE, designed to improve self-esteem in youth who have experienced childhood trauma through a smartphone app, emphasizing its accessibility and real-time support.
- By utilizing a realist evaluation approach, researchers identified key factors that enhance the intervention's effectiveness, such as the sense of privacy from using personal smartphones, which encourages greater engagement and disclosure from users.
- Findings suggest that continuous availability and the opportunity for real-life skill practice enhance the intervention's generalizability, while attention to potential technical issues is crucial for maintaining its positive impact.
Article Synopsis
- Atherosclerotic plaques' destabilization is linked to the presence of specific microvessels, which might be leaky, although evidence is still needed.
- This study aimed to find key molecular drivers of dysfunction in these vessels by analyzing transcriptome data from human atherosclerotic lesions and identifying crucial genes related to microvascular density and inflammation.
- The research highlighted Spectrin Beta Non-Erythrocytic 1 (sptbn1) as a central gene that, when silenced, increased vascular permeability and inflammation, suggesting it plays a significant role in regulating the leaky characteristics of plaque microvessels related to cardiovascular disease.