Publications by authors named "M J D Goodfield"
Article Synopsis
- Hand eczema (HE) is a widespread skin condition affecting up to 10% of the population, causing significant morbidity and work-related issues, with limited treatment guidelines from current research.
- In a study involving 194 UK dermatologists, various treatments were surveyed, with alitretinoin (AL) and psoralen combined with UVA (PUVA) being popular but many clinicians unsure about the best long-term outcomes.
- The ALPHA trial is a randomized controlled study comparing PUVA and AL, aiming to gather data on treatment effectiveness and patient responses over 52 weeks, with ongoing assessments and a focus on genetic factors influencing HE severity.
Objectives: The objectives of this study were to assess the reliability of a novel objective outcome measure, laser Doppler imaging (LDI), its validity against skin biopsy histology and other clinical instruments, including localized cutaneous lupus disease area and severity index (L-CLASI) and visual analogue scale (VAS) score of photographs, and its responsiveness to clinical change with therapy.
Methods: A prospective observational cohort study was conducted in 30 patients with active cutaneous lupus erythematosus (CLE). At baseline and 3 months, disease activity was assessed using L-CLASI and a high resolution LDI system by two assessors.
Objective: When faced with clinical symptoms of scarring alopecia-the standard diagnostic pathway involves a scalp biopsy which is an invasive and expensive procedure. This project aimed to assess if plucked hair follicles (HFs) containing living epithelial cells can offer a non-invasive approach to diagnosing inflammatory scalp lesions.
Methods: Lesional and non-lesional HFs were extracted from the scalp of patients with chronic discoid lupus erythematosus (CDLE), psoriasis and healthy controls.
Background: The European League Against Rheumatism/American College of Rheumatology classification criteria for inflammatory myopathies are able to classify patients with skin-predominant dermatomyositis (DM). However, approximately 25% of patients with skin-predominant DM do not meet two of the three hallmark skin signs and fail to meet the criteria.
Objectives: To develop a set of skin-focused classification criteria that will distinguish cutaneous DM from mimickers and allow a more inclusive definition of skin-predominant disease.