Publications by authors named "M J Cueto"
Background: Pseudomonas aeruginosa (PA) bloodstream infection (BSI) is a common healthcare-associated complication linked to antimicrobial resistance and high mortality. Ongoing clinical trials are exploring novel anti-virulence agents, yet studies on how bacterial virulence affects PA infection outcomes is conflicting and data from real-world clinical populations is limited.
Methods: We studied a multicentre cohort of 773 adult patients with PA BSI consecutively collected during 7-years from sites in Europe and Australia.
Article Synopsis
- The global demand for healthier lifestyles and eco-friendly choices is rising, with consumers seeking natural products that promote well-being.
- The marine environment is explored as a valuable resource for the cosmetics industry, offering bioactive compounds that can be used safely and effectively in various personal care products.
- The manuscript discusses sourcing methods, safety issues, and includes case studies on innovative cosmetic applications developed from marine organisms in Iceland and Italy.
Article Synopsis
- The Shock-CAT study aimed to assess in-hospital mortality and prognosis in cardiogenic shock (CS) patients, comparing those with acute myocardial infarction (AMI) to those without it.
- Out of 382 patients studied, AMI-CS exhibited higher in-hospital mortality rates (37.1%) compared to non-AMI-CS (26.7%), with AMI-CS patients requiring more mechanical circulatory support.
- The IABP-SHOCK II score was found to be more accurate than the CardShock score in predicting 90-day mortality for AMI-CS patients, while both scores performed similarly for non-AMI-CS patients.
Aims: Left ventricular (LV) ring-like scar on cardiac magnetic resonance (CMR) has been linked to malignant arrhythmias in patients with non-ischemic cardiomyopathy. This study aimed to perform a comprehensive evaluation of this phenotype and to identify risk factors for life-threatening arrhythmic events (LAEs), a composite of sudden cardiac death (SCD), aborted SCD, and sustained ventricular tachycardia.
Methods And Results: One-hundred-fifteen patients (median age 39 [IQR 28-52], 42% females) were identified at 6 referral centres.
Subcutaneous delivery of monoclonal antibody therapeutics is often preferred to intravenous delivery due to better patient compliance and overall lower cost to the healthcare system. However, the systemic absorption of biologics dosed subcutaneously is often incomplete. The aim of this work was to describe a human bioavailability prediction method for monoclonal antibodies delivered subcutaneously that utilizes intravenous pharmacokinetic parameters as input.
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