Publications by authors named "M J Collins"
Immune checkpoint inhibitors (ICI), i.e., anti-PD1/PDL1 and anti-CTLA-4, have reshaped the prognosis of many cancers.
View Article and Find Full Text PDFBackground: Relapse after corticosteroid withdrawal in eosinophilic esophagitis is not well understood.
Objectives: Budesonide oral suspension (BOS) 2.0 mg twice daily (b.
Vestibular/ocular motor provocation and state anxiety are both independently linked to poor recovery outcomes following concussion. However, the relationship between these two clinical presentations and their co-occurring effects on concussion recovery outcomes is understudied. The purpose was to examine the co-occurring effects of vestibular/ocular motor provocation and state anxiety following concussion.
View Article and Find Full Text PDFThe anti-apoptotic protein myeloid cell leukemia-1 (Mcl-1) contributes to the pathophysiology of acute myeloid leukemia (AML) and certain B-cell malignancies. Tumor dependence on Mcl-1 is associated with resistance to venetoclax. Voruciclib, an oral cyclin-dependent kinase (CDK) inhibitor targeting CDK9, indirectly decreases Mcl-1 protein expression and synergizes with venetoclax in preclinical models.
View Article and Find Full Text PDFArticle Synopsis
- Histone Deacetylase 1 (HDAC1) removes acetyl groups from histones, impacting gene expression regulation, but its suppression leads to both increases and decreases in gene activity.
- The study used the dTAG system for rapid HDAC1 degradation in mouse embryonic stem cells, which allowed for specific removal within less than an hour.
- After HDAC1 degradation, most differentially expressed genes were upregulated within two hours, and changes in histone acetylation patterns indicated HDAC1's complex role in managing gene expression and enhancer activity for maintaining pluripotency.