Ultrafast synthesis of zirconium-porphyrin framework nanocrystals from alkoxide precursors.

Porphyrinic metal-organic frameworks (MOFs) offer high surface areas and tunable catalytic and optoelectronic properties, making them versatile candidates for applications in phototherapy, drug delivery, photocatalysis, electronics, and energy storage. However, a key challenge for industrial integration is the rapid, cost-effective production of suitable sizes. This study introduces Zr(IV) alkoxides as metal precursors, achieving ultrafast (∼minutes) and high-yield (>90%) synthesis of three well-known Zr-based porphyrinic MOF nanocrystals: MOF-525, PCN-224, and PCN-222, each with distinct topologies.

Assessment of change in end-tidal CO after fluid challenge as a marker of fluid responsiveness as measured by the aortic velocity time integral in healthy anesthetized mechanically ventilated dogs.

Objective: To evaluate if variation in the end-tidal CO partial pressure (∆Petco) after a fluid challenge could predict fluid responsiveness with a sensitivity of 75% and a specificity of 70% in healthy anesthetized and mechanically ventilated dogs.

Design: Diagnostic accuracy study.

Setting: University hospital.

Engineered cell membrane-cloaked metal-organic framework nanocrystals for intracellular cargo delivery.

This investigation demonstrates the development and functionality of cell membrane-cloaked UiO-67 nanosized metal-organic frameworks (NMOFs), which are engineered for precise intracellular delivery of encapsulated cargoes. Utilizing the robust and porous nature of UiO-67, we enveloped these NMOFs with fusogenic cell membrane-derived nanovesicles (FCSMs) sourced from adenocarcinomic human alveolar basal epithelial (A549) cells. This biomimetic coating enhances biocompatibility and leverages the homotypic targeting capabilities of the cell-derived coatings, facilitating direct cytoplasmic delivery and avoiding endolysosomal entrapment.