Longitudinal analysis of adolescents at high risk of depression: Prediction models.

Background: This study aimed to develop a machine-learning-based predictive model to identify adolescents at high risk of depression using longitudinal analysis to determine changes in risk factors over time.

Methods: This longitudinal study used 4 years of data from the Korea Child and Youth Panel Survey (2018-2021). The classification of high-risk depression was the outcome variable, with predictors categorized into general characteristics and personal, family, and school factors.

Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is a devastating X-linked disorder caused by dystrophin gene mutations. Despite recent advances in understanding the disease etiology and applying emerging treatment methodologies, glucocorticoid derivatives remain the only general therapeutic option that can slow disease development. However, the precise molecular mechanism of glucocorticoid action remains unclear, and there is still need for additional remedies to complement the treatment.

RNA-seq-based identification of imidacloprid resistance mechanisms in Nilaparvata lugens and development of diagnostic tools for the CYP6ER1 variant.

Neonicotinoid insecticides, such as imidacloprid, have been used for over three decades to control major agricultural pests, including brown planthopper (Nilaparvata lugens), aphids, and other sap-feeding insects. However, the extensive use of imidacloprid has led to widespread resistance across Asia in many pest populations. Bioassay results demonstrated significant resistance in N.

Metabolic Signaling as a Driver of T Cell Aging.

Aging significantly diminishes T cell immunity, increasing susceptibility to infections and reducing vaccine efficacy in older individuals. Metabolism plays a key role in T cell function, shaping their energy requirements, activation, and differentiation. Recent studies highlight altered metabolic signaling as a pivotal factor in T cell aging, influencing the ability of T cells to maintain quiescence, respond to activation, and differentiate into functional subsets.

Quality and Consumer Acceptance of Chia Seed as an Egg Substitute in Brownies.

Chia seeds have emerged as a promising natural substitute for eggs in various baked products due to their unique gelling properties and ability to bind ingredients. Their gelling abilities closely mimic the moisture-retention functions of eggs in baked goods. The growing interest in plant-based alternatives creates a larger market for more sustainable foods.