Publications by authors named "M J Chandy"
Article Synopsis
- Cannabinoids, derived from the Cannabis plant, are used both medically and recreationally, with THC and CBD being prominent examples, but their effects on peripheral organs like the kidneys need more research.
- * The review highlights the relationship between the endocannabinoid system and kidney function, exploring how cannabinoids might be involved in kidney diseases and their therapeutic potential.
- * Additionally, the review addresses the harmful effects of cannabinoids on kidney health and their link to negative cardiovascular outcomes, emphasizing the need for further understanding in these areas.
Using one's own immune system for curing cancer has been an active field of research in cancer biology and therapeutics. One such opportunity in cellular immunotherapy is adoptive cell transfers. With the recent approval of CAR-T therapy as a cancer treatment, a whole new paradigm of cancer treatment has opened-up, with a ray of hope for relapsed/refractory cancer patients.
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- Melphalan-induced encephalopathy is a rare but serious complication that can occur in patients receiving autologous stem cell transplantation, leading to symptoms such as drowsiness and seizures.
- A review found that about 2% of ASCT patients experienced this condition, with a specific case involving a 63-year-old man with Multiple Myeloma and chronic kidney disease, who developed neurological issues after treatment.
- The report emphasizes the importance of recognizing melphalan-associated encephalopathy as a unique complication in myeloma patients, particularly those with existing kidney problems, and discusses potential management strategies.
Article Synopsis
- This study investigates how effective global longitudinal strain (GLS) is at detecting heart issues in patients experiencing chest pain during treadmill contrast-enhanced stress echocardiography.
- The research involved analyzing data from 33 patients who underwent further testing for coronary artery issues, finding that those with significant blockages had notably lower GLS measurements.
- The findings suggest that GLS can be a helpful diagnostic tool, particularly with a threshold of -20% in stress measurements indicating a reasonable accuracy for ruling out myocardial ischemia.