Advances and issues in the diagnostic differential of malingering versus brain injury.

The past decade has seen numerous advancements in the assessment of malingered brain injury, though the current diagnostic system offers only guidelines in which malingering should be suspected. This article presents an overview of advances in the clinical and neuropsychological assessment of malingering, issues in diagnostic differential, neuropsychological test methods, and special issues presented by the medical-legal context, and other factors which may affect presentations. Cautions and recommendations for practice are presented.

Inflammatory opacities of the vitreous in rifabutin-associated uveitis.

Purpose: To describe rifabutin-associated uveitis with opacities in the inferior and posterior vitreous in three patients with acquired immunodeficiency syndrome.

Method: Case reports of the three patients are presented.

Results: The patients, who were being treated with rifabutin and fluconazole, developed anterior and posterior uveitis.

Perfluorocarbon effects on rabbit blood-retinal barrier permeability.

Studies have been made of the effects of intravitreal perfluoro-n-octane on the permeability to fluorescein of the blood-retinal barrier in rabbits. At day 1 after injection, there is increased aqueous humor fluorescence that reflects the physical disturbance to the eye following injection. From that time through 7 weeks, there is no evidence of any overt toxicity to the blood-retinal barrier.

Intraocular silicone oil effects on rabbit blood-retinal barrier permeability.

Both short- (1 week) and longer-term (7 week) studies have been made on a series of silicone oils to determine their effects on blood-retinal barrier permeability. About 25% of the vitreous humor was replaced with the test oil, and fluorophotometric determinations made after intravenous fluorescein at intervals after oil injection. The short-term studies revealed a uniform disturbance of the eye at 24 hours after oil injection that probably represents the physical disturbance of the eye during injection.