Publications by authors named "M J Cambier"
Article Synopsis
- Pulmonary fibrosis is a serious complication resulting from SARS-CoV-2 infection, and this study examines whether patients with COVID-19 and idiopathic pulmonary fibrosis (IPF) share similar microRNA (miRNA) expressions linked to lung fibrosis.
- The research involved a systematic review of literature from 2010 to January 2022, identifying 34 overlapping miRNAs between COVID-19 and IPF, with some exhibiting upregulation and others downregulation.
- Findings indicate that elevated levels of profibrotic miRNAs and an imbalance in antifibrotic miRNAs contribute to the development of lung fibrosis in patients recovering from COVID-19.
Background: Recommendations and practice patterns for heparin dosing during hemodialysis show substantial heterogeneity and are scantly supported by evidence. This study assessed the variability in unfractionated heparin (UFH) dosing during hemodialysis and its clinical and biological anticoagulatory effects, and identified explanatory factors of heparin dosing.
Methods: Cross-sectional study assessing UFH dosing, coagulation tests - activated partial thromboplastin time (aPTT) and activated clotting time (ACT) before dialysis start, 1 h after start and at treatment end (4 h) - and measurement of residual blood compartment volume of used dialyzers.
Article Synopsis
- The study examines the potential of Krebs von den Lungen 6 (KL-6) as a non-invasive marker for monitoring COVID-19 and predicting post-infection complications like pulmonary fibrosis.
- Researchers analyzed KL-6 levels in 222 COVID-19 patients compared to 70 healthy controls, finding significantly higher levels in infected individuals, which correlated with other disease severity indicators.
- Although KL-6 showed promise as a marker for severity, its relationship with pulmonary function tests was weak, suggesting further research is needed to understand its role in mortality and long-term outcomes.
Tumour-derived extracellular vesicles (EVs) participate in tumour progression by deregulating various physiological processes including angiogenesis and inflammation. Here we report that EVs released by endothelial cells in a mammary tumour environment participate in the recruitment of macrophages within the tumour, leading to an immunomodulatory phenotype permissive for tumour growth. Using RNA-Seq approaches, we identified several microRNAs (miRNAs) found in endothelial EVs sharing common targets involved in the regulation of the immune system.
View Article and Find Full Text PDFRationale & Objective: The EvoCit study was designed to evaluate performance of a heparin-grafted dialyzer during hemodialysis with and without systemic anticoagulation.
Study Design: Randomized, crossover, noninferiority trial. Noninferiority was defined as a difference of≤10% for the primary outcome.