Proteomic analysis of carotid artery plaques with and without vulnerable features on magnetic resonance angiography with vessel wall imaging: a pilot study.

Objective: Extracranial carotid artery pathology accounts for 15% to 20% of ischemic strokes. Advancements in magnetic resonance angiography (MRA) with vessel wall imaging (VWI) have enabled the identification of vulnerable plaques, aiding in risk stratification for neurovascular events. This pilot study aimed to identify proteins in plaques with and without vulnerable features on MRA with VWI.

Whole tissue proteomic analyses of cardiac ATTR and AL unveil mechanisms of tissue damage.

Background: Cardiac AL and ATTR are potentially fatal cardiomyopathies. Current therapies do not address mechanisms of tissue dysfunction because these remain unknown. Our prior work focused on the amyloid plaque proteome, which may not capture tissue-wide proteomic alterations.

Sensing spatial inequality of socio-economic factors for deploying permanent deacons in the UK.

Integrating spatial inequality perspectives in strategic decision-making can ensure positive impacts on resource distribution for public welfare and sustainable development. This study aims to apply evidence-based approaches in deploying permanent deacons. The empirical case study has been conducted at the St Helens denary of the Liverpool archdiocese, UK.