Publications by authors named "M J C Moester"
Background: Coronavirus Disease 2019 (COVID-19) reached the Netherlands in February 2020. To minimize the spread of the virus, the Dutch government announced an "intelligent lockdown". Older individuals were urged to socially isolate completely, because they are at risk of a severe disease course.
View Article and Find Full Text PDFEarly life stage exposure to environmental chemicals may play a role in obesity by altering adipogenesis; however, robust in vivo methods to quantify these effects are lacking. The goal of this study was to analyze the effects of developmental exposure to chemicals on adipogenesis in the zebrafish (). We used label-free Stimulated Raman Scattering (SRS) microscopy for the first time to image zebrafish adipogenesis at 15 days post fertilization (dpf) and compared standard feed conditions (StF) to a high fat diet (HFD) or high glucose diet (HGD).
View Article and Find Full Text PDFArticle Synopsis
- The amphiphilic ruthenium complex [3](PF6 )2 exhibits stable properties in dark environments but becomes photosensitive, releasing compounds when exposed to blue light.
- It is as cytotoxic as cisplatin against several human cancer cell lines under dark conditions, showing effectiveness at micromolar concentrations.
- The complex behaves differently depending on its concentration: at low levels, it functions as a monomer causing internal delivery of another complex, while at higher concentrations, it disrupts cell membranes and leads to non-apoptotic cell death.
Both bone morphogenetic protein (BMP) and Wnt signaling have significant roles in osteoblast differentiation and the interaction between BMP and Wnt signaling is well known. Sclerostin is an important inhibitor of bone formation, inhibiting Wnt signaling and downstream effects of BMP such as alkaline phosphatase activity and matrix mineralization in vitro. However, little is known about the effect of BMP and Wnt signaling interaction on the regulation of SOST, the gene encoding sclerostin.
View Article and Find Full Text PDFContext: Sclerostin and Dickkopf 1 (DKK1) are antagonists of the canonical Wnt signaling pathway, both binding to the same low-density lipoprotein receptor-related protein 5/6 on osteoblasts, thereby inhibiting bone formation. It is not known whether there is an interaction between sclerostin and DKK1.
Objective: We examined whether a lack of sclerostin is compensated by increased DKK1 levels.