Microwave Heating and Self-Healing Performance of Asphalt Mixtures Containing Metallic Fibres from Recycled Tyres.

This study investigates how recycled metal fibres from End-of-Life Tyres (ELTs) affect both microwave heating efficiency and crack healing properties in dense asphalt mixtures. The aim is to improve tyre recyclability by using their fibres in asphalt and exploring their self-healing potential with microwave heating. To achieve this, four dense asphalt mixture designs were studied in the laboratory.

Erythema nodosum as first clinical manifestation of metastatic neuroendocrine tumor: A case report.

Erythema nodosum (EN) is a reactive inflammatory panniculitis, which has been associated with medications, infections, autoimmune and autoinflammatory diseases. It has rarely been associated with neoplasms. We present the case of a 61-year old woman who was admitted because 3-week history of painful erythematous subcutaneous nodules on the lower limbs clinically consistent with EN, which was confirmed by skin biopsy.

Epigenetic reprogramming in pediatric gliomas: from molecular mechanisms to therapeutic implications.

Brain tumors in children and adults differ greatly in patient outcomes and responses to radiotherapy and chemotherapy. Moreover, the prevalence of recurrent mutations in histones and chromatin regulatory proteins in pediatric and young adult gliomas suggests that the chromatin landscape is rewired to support oncogenic programs. These early somatic mutations dysregulate widespread genomic loci by altering the distribution of histone post-translational modifications (PTMs) and, in consequence, causing changes in chromatin accessibility and in the histone code, leading to gene transcriptional changes.

Cell and gene therapy in neuro-oncology.

The majority of primary brain tumors are gliomas, among which glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. GBM has a median survival of 18-24 months, and despite extensive research it remains incurable, thus novel therapies are urgently needed. The current standard of care is a combination of surgery, radiation, and chemotherapy, but still remains ineffective due to the invasive nature and high recurrence of gliomas.