Publications by authors named "M J Buchanan"
Article Synopsis
- - The study compares the outcomes of two gastrostomy tube placement techniques—laparoscopic (LAP) and percutaneous endoscopic (PEG)—in pediatric patients, focusing on complications and the need for additional procedures.
- - Researchers reviewed records of 688 patients aged 0-18 who had GT placements, finding that LAP patients were generally younger and lighter than PEG patients, but both groups had similar rates of major complications.
- - Results showed that PEG patients had a higher likelihood of developing skin infections, while no LAP placements failed during the study period, indicating potential advantages of LAP over PEG in certain aspects.
Article Synopsis
- The text summarizes historical climate change trends in New York City (NYC) and discusses new scientific methods for projecting future changes related to sea level rise, temperature, and precipitation across different greenhouse gas emissions scenarios.
- It highlights the challenges posed by "hot models" from the 6th phase of the Coupled Model Intercomparison Project (CMIP6) and their implications for climate projections in NYC, as well as the factors contributing to extreme heat events and unequal heat exposure in urban areas.
- The piece identifies critical areas of risk related to extreme weather events and suggests future research opportunities, particularly in understanding the limitations of current models and their spatial resolution concerning urban heat dynamics.
Many tumor types harbor alterations in the Hippo pathway, including mesothelioma, where a high percentage of cases are considered YAP1/TEAD dependent. Identification of autopalmitoylation sites in the hydrophobic palmitate pocket of TEADs, which may be necessary for YAP1 protein interactions, has enabled modern drug discovery platforms to generate compounds that allosterically inhibit YAP1/TEAD complex formation and transcriptional activity. We report the discovery and characterization of a novel YAP1/TEAD inhibitor MRK-A from an aryl ether chemical series demonstrating potent and specific inhibition of YAP1/TEAD activity.
View Article and Find Full Text PDFThe role of social support in reducing the long-term burden of cumulative childhood adversity on adulthood internalising disorder.
Soc Psychiatry Psychiatr Epidemiol
December 2024
Purpose: Previous research indicates that social support is protective for the mental health outcomes of exposure to childhood adversity. However, the impact of social support as a protective factor following exposure to cumulative childhood adversity is understudied with prospective longitudinal data. The aim of this present study was to examine how social support mediates the impact of cumulative exposure to childhood adversity on internalising disorder in adulthood.
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