Publications by authors named "M J Bronstein"
Background: Extracorporeal membrane oxygenation (ECMO) has emerged as a critical intervention in the management of patients with trauma-induced cardiorespiratory failure. This study aims to compare outcomes in patients with severe thoracic injuries with and without venovenous extracorporeal membrane oxygenation (VV-ECMO).
Methods: We performed a retrospective cohort study on Trauma Quality Improvement Program (2017-2021) and included all patients with isolated blunt thoracic injuries with Abbreviated Injury Scale score of ≥4 who required intubation.
Molecular recognition events between proteins drive biological processes in living systems. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules. Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field.
View Article and Find Full Text PDFBackground: Obesity is a known risk factor for thromboembolic complications in trauma patients. The aim of our study is to evaluate the prevalence of thrombotic complications in obese geriatric patients.
Methods: We performed a retrospective analysis of TQIP (2017-2019).
Article Synopsis
- - Structure-based drug design (SBDD) focuses on creating small molecules that accurately target specific proteins, using structural data to help propose new drug candidates.
- - Current methods typically require extensive dataset preparation and retraining for different tasks, while our approach introduces a single pretrained model that can handle multiple design challenges.
- - We introduce DiffSBDD, a diffusion model that generates new ligands based on protein structures, and demonstrate how it can be enhanced with constraints for better drug candidate quality.