Publications by authors named "M J Brack"
A systematic review (SR) of published efficacy studies in visceral leishmaniasis (VL) was undertaken to describe methodological aspects of design, conduct, analysis, and reporting. Studies published during 2000-2021 and indexed in the Infectious Diseases Data Observatory VL library of clinical studies were eligible for inclusion (N = 89 studies). Of the 89 studies, 40 (44.
View Article and Find Full Text PDFBackground: Occurrences of relapse after 6-months post-treatment has been reported in recent Visceral Leishmaniasis (VL) efficacy studies. A meta-analysis was carried out to quantify the proportion of relapses observed at and beyond 6-months using the Infectious Diseases Data Observatory (IDDO) systematic review (SR) database.
Methods: Studies in the IDDO SR database (1983-2021; 160 studies) were eligible for inclusion if follow-up was at least 6-months, relapse was clearly reported, and patients with HIV coinfections were excluded.
Article Synopsis
- - Lymphatic filariasis (LF) is a serious neglected tropical disease with ongoing global efforts to eliminate it as a public health problem, yet nearly 900 million people still need treatment despite over 9 billion treatments distributed since 2000.
- - A systematic literature review was conducted to gather individual participant data (IPD) related to LF treatment effectiveness and morbidity management by analyzing studies from various databases between 2000 and 2023.
- - From 138 eligible studies across 23 countries, researchers identified nearly 15,000 IPD related to infection indicators and approximately 6,100 IPD concerning clinical morbidity, revealing significant gaps in understanding treatment responses.