Publications by authors named "M J Boyle"
Form-function relationships often have tradeoffs: if a material is tough, it is often inflexible, and vice versa. This is particularly relevant for the elephant trunk, where the skin should be protective yet elastic. To investigate how this is achieved, we used classical histochemical staining and second harmonic generation microscopy to describe the morphology and composition of elephant trunk skin.
View Article and Find Full Text PDFObjective: To evaluate the impact of Nurse-Family Partnership (NFP), a home-visiting programme, on exploratory maternal outcomes in British Columbia (BC), Canada.
Design: Pragmatic, parallel arm, randomised controlled trial conducted October 2013-November 2019. Random allocation of participants (1:1) to comparison (existing services) or NFP (plus existing services).
Purpose: There is an increasing incidence of young breast cancer (YBC) patients with uncertainty surrounding the factors and patterns that are contributing.
Methods: We obtained characteristics and survival data from 206,156 YBC patients (≤ 40 years of age) diagnosed between 2005 and 2019 from the National Cancer Database (NCDB). Patients were subdivided into two comparison groups based on year of diagnosis (2005-2009, Old vs.
Our understanding of brain iron regulation and its disruption in disease is limited. Excess iron affects motor circuitry, contributing to Parkinson's disease (PD) risk. The molecular mechanisms regulating central iron levels, beyond a few well-known genes controlling peripheral iron, remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- The IASLC TNM proposal suggests that pure ground glass nodules (GGNs) under 30 mm should be classified as non-invasive, but this study aimed to determine the actual rate of invasive cancer in these nodules.
- An analysis of 3874 individuals from various studies found that the prevalence of minimally invasive and invasive adenocarcinoma in these GGNs was approximately 42.4%, indicating a significant risk for malignancy.
- The findings challenge existing guidelines, as most studies were retrospective and highlighted substantial variability in results based on patient selection, emphasizing that smaller GGNs may not be as benign as previously considered.