Publications by authors named "M J Boeckh"
Background: Early host immunity to acute respiratory infections (ARIs) is heterogenous, dynamic, and critical to an individual's infection outcome. Due to limitations in sampling frequency/timepoints, kinetics of early immune dynamics in natural human infections remain poorly understood. In this nationwide prospective cohort study, we leveraged a Tasso-SST based self-blood collection and stabilization tool (homeRNA) to profile detailed kinetics of the presymptomatic to convalescence host immunity to contemporaneous respiratory pathogens.
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- - Recent advancements in cytomegalovirus (CMV) prevention and treatment have emerged from pivotal clinical trials, focusing on tailored strategies for hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT).
- - The review highlights methods to boost CMV-specific immunity using vaccination, monoclonal antibodies, and virus-specific T-cells, alongside observational studies on CMV cell-mediated immunity assays to refine preventive and treatment approaches.
- - Emphasizing the need to enhance CMV-specific immunity is vital for reducing CMV's detrimental effects in transplant recipients, especially as infections in CAR-T therapy patients and other immunocompromised groups rise, although these areas are not covered in this review.
Congregate homeless shelters are disproportionately affected by infectious disease outbreaks. We describe enterovirus epidemiology across 23 adult and family shelters in King County, Washington, USA, during October 2019-May 2021, by using repeated cross-sectional respiratory illness and environmental surveillance and viral genome sequencing. Among 3,281 participants >3 months of age, we identified coxsackievirus A21 (CVA21) in 39 adult residents (3.
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- The study looks at how different groups of people in Seattle, based on their race, income, and gender, have different chances of getting paid sick leave (PSL).
- About 66.6% of the people surveyed had access to PSL, with higher rates among Asian and White respondents, while Black and low-income households had much lower access.
- It finds that having access to PSL is really important for everyone’s health, especially during situations like the COVID-19 pandemic, and suggests that better policies could help everyone stay healthier.