Publications by authors named "M J Beecroft"
The UK has fallen from fourth to 10th place in the global ranking for clinical trial activities in the past 6 years. Due to the limited capacity of the clinical trial pharmacy workforce and delays in providing pharmacy approvals, pharmacy has been identified as one of the constraining services that delays the set-up and delivery of clinical trials. To tackle this problem, we developed a single pharmacy review process for multicentre trials across Greater Manchester (GM) and tested its feasibility and implementation in our region.
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- The study aimed to investigate the clinical significance and potential causes of low serum alkaline phosphatase (sALP) levels in children, emphasizing the importance of age-and sex-specific reference ranges in paediatrics.
- During the study period from 2015 to 2017, about 9.2% of evaluated paediatric patients showed low sALP, with the majority experiencing transient low levels; however, 9.6% had persistently low levels, often associated with prolonged immobilization or inflammatory bowel disease.
- The findings suggest that healthcare providers should take low sALP levels seriously, considering further evaluation and potential underlying conditions, as a notable percentage of patients exhibited persistently low sALP without clear reasons.
Background: This report describes a unique case of long-term survival of a young girl who was diagnosed with severe, rapidly progressive lysosomal acid lipase deficiency (LAL-D; historically "Wolman disease") at three months of age and began receiving therapeutic interventions at four months of age. This disease involves rapidly progressive multisystemic impairments and limited survival (6-12 months) without treatment.
Methods: Case report taking into account clinical aspects and patient management including a semi-structured interview with the main family caregiver.
Objective: To understand the effect of changing from cytology-based to primary HPV screening on the positive predictive value (PPV) of colposcopy referrals for cervical intraepithelial neoplasia (CIN) in a cohort offered HPV vaccination.
Design: Retrospective pre/post observational cohort study.
Setting: Scotland.
Bacterial growth and proliferation can be restricted by limiting the availability of metal ions in their environment. Humans sequester iron, manganese, and zinc to help prevent infection by pathogens, a system termed nutritional immunity. Commercially used chelants have high binding affinities with a variety of metal ions, which may lead to antibacterial properties that mimic these innate immune processes.
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