Comparative study of ergosterol and 7-dehydrocholesterol and their endoperoxides: Generation, identification, and impact in phospholipid membranes and melanoma cells.

Melanoma is an aggressive cancer that has attracted attention in recent years due to its high mortality rate of 80%. Damage caused by oxidative stress generated by radical (type I reaction) and singlet oxygen, O (type II reaction) oxidative reactions may induce cancer. Thus, studies that aim to unveil the mechanism that drives these oxidative damage processes become relevant.

An Unusual Presentation of Plantar Psoriasis: A Case Report.

Plantar psoriasis is a chronic inflammatory skin disorder, typically characterized by erythematous plaques with thick silvery scales localized on the soles. This condition can significantly impair patients' quality of life, particularly through pain and mobility challenges. It is considered a subtype of plaque psoriasis but presents unique diagnostic and therapeutic challenges due to its specific location.

Benign Yellow Dot Maculopathy: A Case Series of Patients With a Recently Discovered Macular Phenotype.

Benign yellow dot maculopathy (BYDM) is a recently described rare, asymptomatic, early onset, and non-progressive macular phenotype. It is characterized by the presence of multiple white-yellow dots encircling the fovea, which are hyperautofluorescent on fundus autofluorescence. Here, we expand on the few reports available by presenting a case series of five Portuguese patients with clinical BYDM phenotype and congruent multimodal imaging, including the second reported unilateral case.

Heavy atom effects on synthetic pyranoanthocyanin analogues.

Pyranoflavylium cations are synthetic analogues of pyranoanthocyanins, the much more color-stable compounds that are formed spontaneously from grape anthocyanins during the maturation of red wines. In the present work, our studies of the photophysical properties of pyranoanthocyanin analogues are extended to include nine pyranoflavylium cations substituted with one or two bromo and/or iodo heavy atoms. The room temperature fluorescence, 77 K fluorescence and phosphorescence, triplet formation in solution, and sensitized singlet oxygen formation, with excited state acidity suppressed by the addition of trifluoroacetic acid, are compared to those of similar pyranoflavylium cations that do not contain a heavy atom.

Sustainable Solid-State Sodium-Ion Batteries Featuring Ferroelectric Electrolytes.

Solid-state batteries offer significant advantages but present several challenges. Given the complexity of these systems, it is good practice to begin the study with simpler models and progressively advance to more complex configurations, all while maintaining an understanding of the physical principles governing solid-state battery operation. The results presented in this work pertain to cells without traditional electrodes, thus providing a foundation for guiding the development of fully functional solid-state cells.