Publications by authors named "M J Avram"
Background: Permanent hair reduction is an integral part of gender-affirming medical care, especially for transgender patients undergoing surgeries such as phalloplasty and vaginoplasty. Hair removal helps reduce complications and alleviate gender dysphoria associated with unwanted facial and body hair.
Objective: To examine the methods, efficacy, and access issues of hair removal in transgender patients, with a focus on its role in surgical preparation and gender dysphoria reduction.
Article Synopsis
- Recent research indicates that blocking the interaction between valosin-containing protein (VCP) and mutant huntingtin (mtHtt) can help prevent mitochondrial damage in Huntington's disease models.
- A newly developed protein-like polymer (PLP) has shown effectiveness in cellular and animal models, significantly inhibiting mitochondrial destruction and proving more stable than control oligopeptides.
- PLP has a remarkably longer circulation half-life (152 hours) and outperforms free peptide in efficacy tests, suggesting it could be a promising platform for developing treatments for central nervous system disorders.
Article Synopsis
- Exosomes show potential for treating hair and skin diseases by promoting hair growth through various cellular mechanisms, but research on their safety in humans is limited.
- A review of 48 studies highlighted that while side effects were rare for exosome treatments in alopecia, there have been serious adverse events reported in other dermatological applications.
- The conclusion stresses the need for more thorough clinical trials and consistent manufacturing standards to establish the efficacy and safety of exosome treatments.