Publications by authors named "M J Andrada-Serpa"
Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil.
BMC Infect Dis
November 2018
Article Synopsis
- HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological disease linked to HTLV-1 infection, with cytokines playing a key role in its inflammatory response and progression.
- A study in Rio de Janeiro evaluated genetic polymorphisms in cytokine genes among HAM/TSP patients and asymptomatic HTLV-1 carriers, finding no significant links between these polymorphisms and disease outcomes.
- Despite some correlations between certain genotypes and higher proviral load in HAM/TSP patients, the research concluded that cytokine polymorphisms do not appear to be associated with the risk of developing HAM/TSP in Brazilian individuals infected with HTLV-1.
Objectives: Human T-cell lymphotropic virus type 1 (HTLV-1) infection is associated with neurological abnormalities, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and peripheral neuropathy (PN). Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease worldwide, and causes PN in approximately 9% of patients. Because the interplay between these potentially neuropathogenic viruses in the same individual is still poorly understood, the clinical and laboratory outcomes of co-infected patients were evaluated and compared with those of controls.
View Article and Find Full Text PDFHigh IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development.
Intervirology
January 2016
Background/aims: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Therefore, we investigated parameters to discriminate HTLV-1 asymptomatic carriers (ACs) with an increased chance to develop HAM/TSP.
View Article and Find Full Text PDFThe human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with neoplasias and inflammatory diseases, such as adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected individuals present a spontaneous T lymphocyte proliferation. This phenomenon is related to the HTLV-1-proviral load and the persistence of the infection.
View Article and Find Full Text PDFSickle cell disease: acute clinical manifestations in early childhood and molecular characteristics in a group of children in Rio de Janeiro.
Rev Bras Hematol Hemoter
July 2013
Objectives: To describe clinical events of sickle cell disease and the correlation with β-globin haplotypes and α-thalassemia in under 6-year-old children.
Methods: A retrospective study was conducted of under 6-year-old children from the neonatal screening program in Rio de Janeiro. Forty-eight male and 48 female children were enrolled in this study, 79 with sickle cell anemia and 17 with hemoglobin SC.