Prorenin-renin axis in synovial fluid in patients with rheumatoid arthritis and osteoarthritis.

This study was undertaken 1) to determine whether or not renin is present in synovial fluid in patients with rheumatoid arthritis and osteoarthritis, and, if present, 2) to investigate whether it is synthesized in synovial fluid, or it is only transported from the circulation into the synovial cavity. The active renin concentration (indirect) was measured with angiotensin I radioimmunoassay kits. Inactive renin was converted into active renin with Sepharose-bound trypsin.

Inactive renin release from the human arm vascular wall during upper arm occlusion: relation to beta-adrenoceptors.

To investigate the extrarenal release of renin, plasma active renin (PAR) and plasma trypsin activatable or inactive renin (PIR) in blood taken simultaneously from bilateral median cubital veins were measured in seven normal men before and after occlusion of the right upper arm with a standard cuff inflated halfway between systolic and diastolic blood pressures for 15 min. After 15 min, both PAR (P less than 0.05) with PIR (P less than 0.

Increased furosemide-sensitive sodium influx into erythrocytes in non-insulin-dependent diabetes mellitus associated with hypertension.

Our previous study demonstrated increased sodium (Na+) influx into ouabain-treated erythrocytes in diabetic patients with hypertension. The present study was designed to estimate the effect of furosemide on the Na+ influx in non-insulin-dependent diabetes mellitus (NIDDM) with hypertension. Both Na+ influx in the absence of furosemide (total Na+ influx; TNaI) and furosemide-sensitive Na+ influx (FSNaI) were increased in patients with essential hypertension (group 1, n = 22) than those in non-diabetic, normotensive control subjects without family history of hypertension (control group, n = 26, P less than 0.

[A case of pseudo-Bartter's syndrome associated with hypokalemic myopathy].

A case of pseudo-Bartter's syndrome associated with hypokalemic myopathy was presented. A 37-year-old housewife was admitted to our hospital because of muscle cramps with muscle weakness and tetany. There was a history of facial edema and constipation, which have been managed with "Kanpo medicine (Chinese medicine)" and laxatives for several years.