Publications by authors named "M Iwaya"
Renal medullary carcinoma is a rare, high-grade carcinoma arising in the renal medulla, which is usually associated with sickle cell trait, and there are very few documented cases in the Japanese population. We report a case of renal medullary carcinoma, immunohistochemically defined as SMARCB1 deficient, in a 67-year-old Japanese woman without a history of sickle cell trait. Somatic mutation of SMARCB1 and an EML4::ALK fusion gene were identified by comprehensive genomic profiling.
View Article and Find Full Text PDFObjective: We investigated and compared the long-term (6-month) histologic changes in a rat model of sublobar resection created using electrocautery or stapler techniques.
Methods: Nine-week-old male rats were anesthetized and intubated; thoracotomy with sublobar resection was performed in the right middle lobe using electrocautery or stapler techniques. Histological examination was performed at 2, 4, 8, 12, and 24 weeks post-surgery to assess long-term effects on lung tissue repair and morphologic changes.
Article Synopsis
- This study investigates the significance of immune cell distribution in lung cancer, particularly how it relates to a form of invasion called STAS (spread through air spaces), which is linked to worse outcomes.
- Researchers analyzed tissue samples from 283 patients who had surgery for lung cancer, focusing on the presence of various immune cells around the tumor edges compared to the center.
- Findings showed that higher levels of certain immune cells (CD4, CD8, and FoxP3) near the tumor edges were associated with a higher risk of cancer recurrence, emphasizing the importance of immune cell patterns in predicting patient prognosis and potential treatment strategies.
Article Synopsis
- LGR5 is a marker for cancer stem cells and its expression in extrahepatic cholangiocarcinoma (ECC) was studied using a sensitive RNA detection method in 53 cases.
- The study found that higher LGR5 expression was linked to well- to moderately differentiated cancers, which showed better overall and disease-free survival rates compared to poorly differentiated cancers.
- The results indicate that LGR5 could serve as a valuable prognostic marker for patients with ECC, potentially guiding treatment decisions.