Publications by authors named "M Iwan"
Article Synopsis
- Breast cancer is a major health issue for women globally, prompting research for new treatments that specifically target proteins involved in tumor growth.
- Researchers developed and tested new compounds called rhodanine-piperazine hybrids aimed at key tyrosine kinases like VEGFR, EGFR, and HER2, identifying three that showed notable anticancer activity.
- One compound, in particular, demonstrated strong effectiveness against certain breast cancer cell lines and had favorable binding interactions with the target proteins, suggesting it could be a promising candidate for future drug development.
Two compounds, benzyl-2-(amino(pyrazin-2-yl)methylene)-1-methylhydrazine-1-carbodithioate (L) and its copper(ii) complex Cu(L) were synthesized and studied in terms of their physicochemical properties, including single crystal, spectroscopic and magnetic properties; simulations, including DFT calculations and pharmacokinetic profile analysis; and biological activity. The Cu(L) compound was found to exhibit good anticancer activity against A375, PANC-1, MKN-74, T-47D, HeLa, and NCI-H1563 cells, with the IC value against the HeLa cell line reaching 17.50 μM, significantly surpassing the activity of the organic ligand.
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- * The extract showed promising effects against nematodes and exhibited stronger antibacterial activity against Gram-positive bacteria compared to Gram-negative bacteria, along with some antifungal and antiviral properties.
- * Additionally, the extract demonstrated moderate cytotoxicity towards human cervical adenocarcinoma cells, suggesting its potential for further research in antiparasitic applications.
The intensive development of extraction methods based on μ-SPE extraction contributes to the increased interest in the synthesis of new sorption materials. This work presents the characterization of polystyrene fibers and polystyrene fibers blended with ZrO particles or polyaniline obtained by electrospinning and their use in the extraction of selected psychoactive drugs from biological samples. The characteristic of produced fibers is made by performing SEM images, measuring average fiber diameter, and examining their sorption abilities.
View Article and Find Full Text PDFOur research aimed to evaluate how the rigidification of the characteristic 3-aminopropyloxy linker by incorporating it into 1,5-benzoxazepines affects the potency of histamine H receptor (HR) antagonists/inverse agonists. This research constitutes a starting point for the full characterization of the pharmacological properties of this group of compounds. Several 1,5-benzoxazepine derivatives were synthesized and pharmacologically tested as potential HR antagonist/inverse agonists.
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