Publications by authors named "M Iwakoshi"
A generally applicable method to discover xenobiotic metabolites is important to safely and effectively develop xenobiotics. We propose an advanced method to detect and identify comprehensive xenobiotic metabolites using stable isotope labeling, liquid chromatography coupled with benchtop quadrupole Orbitrap high-resolution tandem mass spectrometry (LC/HRMS/MS), data mining techniques (alignment, peak picking, and paired-peaks filtering), in silico metabolism prediction, and time-dependent profiling. The LC/HRMS analysis was carried out using Arabidopsis T87 cultured cells treated with unlabeled or with C- or H-labeled 2,4-dichlorophenoxyacetic acid (2,4-D).
View Article and Find Full Text PDFPurpose: To determine factors affecting physical activity in outpatients with gastrointestinal cancer.
Methods: This observational study applied the International Physical Activity Questionnaire(IPAQ)to identify factors affecting physical activity in outpatients(male, n=51; female, n=24; mean age, 64.2±10.
Article Synopsis
- Mowat-Wilson syndrome (MWS) is a genetic disorder linked to intellectual disabilities, distinct facial features, and various organ anomalies, primarily caused by mutations in the ZEB2 gene.
- A study identified 13 nonsense and 27 frameshift mutations in 40 new MWS patients in Japan, noting similarities with previously reported cases but differences in the frequency of certain symptoms like microcephaly and Hirschsprung disease.
- The research highlighted that mutations affecting ZEB2 stability, particularly a specific frameshift mutation, lead to low levels of the associated protein, which contributes to the development of MWS.
[Field report of cancer rehabilitation at Kensekai Dongo Hospital].
Gan To Kagaku Ryoho
February 2013
In 2010, a newly-created medical fee was established for "Cancer Patient Rehabilitation." We acquired the facility criteria for cancer rehabilitation in August 2011. In December 2005, we started a preventive rehabilitation program to provide comprehensive respiratory physical therapy.
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