Publications by authors named "M Iu Sandin"
Background: Decision tree algorithms, obtained by machine learning, provide clusters of patients with similar clinical patterns by the identification of variables that best merge with a given dependent variable.
Methods: We performed a multicenter registry, with 7 hospitals form Spain, of patients with, or high-risk of having, coronary heart disease (CHD). Elevated Lp(a) was defined as >50 mg/dl.
Low-density lipoprotein cholesterol (LDLc) is the lead effector of atherosclerosis and main treatment target. Bempedoic acid is a novel oral drug in the therapeutic armamentarium which is able to reduce LDLc. The objectives of this study were (1) to select the potential patients for administering bempedoic acid such as those with a very high cardiovascular risk in which objectives of LDLc were not achieved despite conventional treatment with PCSK9 inhibitors (PCSK9i) and/or statins and ezetimibe and (2) to estimate the cost-effectiveness of bempedoic acid in different scenarios.
View Article and Find Full Text PDFObjectives: This was a retropective study of invasive group B streptococcal (GBS) infections isolated from blood, cerebrospinal fluid (CSF), synovial fluid, peritoneal fluid, pleural fluid, pericardial fluid and corpus vitreum in a defined region in southwest Sweden over a 14-year period.
Design: Information on all invasive GBS infections was obtained from all four bacteriological laboratories in the region, with data obtained from individual patient records.
Results: GBS was isolated from normally sterile body fluids in 1244 samples (579 from females and 665 from males) from 1101 patients.
Article Synopsis
- Monoclonal antibodies targeting PCSK9 significantly lower LDL cholesterol levels by about 55% in patients, but their impact on other lipid parameters like cholesterol remnants is less clear.
- A study analyzing data from 652 patients across 14 hospitals in Spain showed that treatment with PCSK9 inhibitors not only reduced LDL cholesterol but also led to significant decreases in other lipid measures, including the triglycerides-to-HDL ratio and cholesterol remnants.
- The findings indicate that over one-third of patients achieved LDL cholesterol below 55 mg/dl and lower cholesterol remnants, suggesting that PCSK9 inhibitors are effective in managing lipid residual risk as well as LDL cholesterol levels.
Approximately 20% of locally advanced rectal cancers treated with neoadjuvant therapy achieve a pathologic complete response, but approximately 10% of them present residual nodal metastases (ypT0N+). We aimed this research to compare the survival rates of ypT0/ypTisN+ and stage 3a rectal cancer patients. A large multicenter study recently investigated ypT0/ypTis rectal cancers treated between 2005 and 2015 in Italy and Spain.
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