Recent X-ray and cryo-EM studies of 70S ribosome complexes containing different types of messenger RNAs (mRNA) and transfer RNA (tRNA) have been reviewed. Changes of the mRNA path on the ribosome at initiation and elongation states have been described. Authors suggested, that the specific region of ribosomal 30S subunit ("platform") is a ribosome binding site of regulatory domains of mRNA which locates on the non-translated 5'-end of the mRNA.
View Article and Find Full Text PDFA new technique of atomic tritium bombardment has been used to study the surface topography of Escherichia coli ribosomes and ribosomal subunits. The technique provides for the labeling of proteins exposed on the surface of ribosomal particles, the extent of protein labeling being proportional to the degree of exposure. The following proteins were considerably tritiated in the 70S ribosomes: S1, S4, S7, S9 and/or S11, S12 and/or L20, S13, S18, S20, S21, L1, L5, L6, L7/L12, L10, L11, L16, L17, L24, L26 and L27.
View Article and Find Full Text PDFThe use of therapeutic hyperthermia in sauna as part of multimodality therapy of 107 patients with asthma and chronic bronchitis resulted in a rapid time course of clinical symptoms of diseases, reduced the adaptation period at a health resort, produced a bronchodilatatory effect and helped to return cardiodynamics to normal permitting one to make use of sauna as a pathogenetic therapeutic method for patients with the obstructive syndrome in bronchopulmonary diseases.
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