Publications by authors named "M Itsuno"
Introduction: Tau protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD) and in regulating neuronal excitability. Among tau-coding microtubule associated protein tau () gene mutations, the A152T mutation is reported to increase the risk of AD and neuronal excitability in mouse models.
Methods: To investigate the effects of gene expression and its mutations on neuronal activity in human neurons, we employed genome editing technology to introduce the A152T or P301S mutations into induced pluripotent stem cells (iPSCs).
Article Synopsis
- Researchers developed a co-culture model using induced pluripotent stem cells (iPSCs) to better simulate brain interactions by combining neurons and astrocytes, overcoming the limitations of single-cell type monoculture models.
- This new model demonstrated increased neuronal activity and structural changes, such as astrocyte branching and synapse formation, which are vital for reflecting a more realistic brain environment.
- The co-culture model of iPSCs from a familial Alzheimer's disease patient exhibited disease-specific phenotypes, like astrogliosis, that were not present in monoculture models, highlighting its potential for improving disease modeling.
Human neural cell models derived from induced pluripotent stem cells (iPSCs) have been widely accepted to model various neurodegenerative diseases such as Alzheimer's disease (AD) . Although the most common sources of iPSCs are fibroblasts and peripheral blood mononuclear cells, the collection of these cells is invasive. To reduce the donor's burden, we propose the use of urine-derived cells (UDCs), which can be obtained non-invasively from a urine sample.
View Article and Find Full Text PDFA rare case of malignant lymphoma of the stomach after treatment for hepatocellular carcinoma (HCC) is reported. A 72-year old man presented with a large mass on the right hypochondrium, which was diagnosed as HCC associated with chronic hepatitis C with cirrhosis. The inoperable tumor was treated conservatively with cisplatin, etoposide, carboplatin, and Lipiodol infused into the hepatic artery, together with transcatheter arterial embolization.
View Article and Find Full Text PDF[A case of non-B, non-C, juvenile hepatocellular carcinoma with brain metastasis].
Nihon Shokakibyo Gakkai Zasshi
October 1996