Publications by authors named "M Itoigawa"
Article Synopsis
- Researchers determined the structures of new compounds called flavacitropones A and B, which are homoacridone-flavanone dimers from the plant species (Sims) Kurz in the Rutaceae family.
- Flavacitropone A was tested for its biological effects on cytotoxicity and inflammatory markers in a specific rat cell line (RBL-2H3).
- The results showed that flavacitropone A reduced the release of TNF-α, a pro-inflammatory cytokine, but did not affect histamine release.
We separated and structurally elucidated three new acridone alkaloids (glycomontamine A (), B (), and C ()), together with three known compounds (glycofoline, kokusaginine and dictamnine) from the acetone extract of (Blume) D.Dietr. branches collected in Thailand.
View Article and Find Full Text PDFSargassum carpophyllum (Sargassaceae) is a brown seaweed that contains phlorotannins, which are phloroglucinol polymers with reported anti-inflammatory activities. The phlorotannins 2-[2-(3,5-dihydroxyphenoxy)-3,5-dihydroxyphenoxy]-1,3,5-benzenetriol (1), 2,2'-[[2-(3,5-dihydroxyphenoxy)-5-hydroxy-1,3-phenylene]bis(oxy)]bis(1,3,5-benzenetriol) (2), and 2-[2-[4-[2-(3,5-dihydroxyphenoxy)-3,5-dihydroxyphenoxy]-3,5-dihydroxyphenoxy]-3,5-dihydroxyphenoxy]-1,3,5-benzenetriol (3) were isolated from S. carpophyllum.
View Article and Find Full Text PDFFour new compounds (derriscandenon D (), E (), F (), G ()) and six known isoflavones (warangalone (), millewanin E (), rhynedlin A (), 6,8-diprenylgenistein (), isolupalbigenin (), isoscandinone ()) were isolated from the acetone extract of the branches of . These compounds were assayed for cell viability using the human lung carcinoma cell line A549, colorectal carcinoma cell line Colo205, epidermoid carcinoma cell line KB, the human acute lymphoblastic leukaemia cell line NALM-6, and human dermal fibroblasts. Compounds and significantly decreased the viability of KB cells, with IC values of 2.
View Article and Find Full Text PDFObjectives: Acridone alkaloids from Citrus and their derivatives show various kinds of biological activity. However, the anticancer activities of dimeric acridone alkaloids with unique structures and the molecular mechanism of these effects are poorly understood.
Methods: We investigated the cytotoxicity effects of dimeric acridone alkaloids isolated from Marsh grapefruit on human myeloid leukaemia HL-60 cells.