Publications by authors named "M Iseki"

Background: There is a complex relationship between tobacco use and pain. Nicotine provides temporary pain relief but increases the risk of chronic pain. This study aimed to investigate use of tobacco for pain relief and its association with demographic and medical characteristics in Japan.

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In September 2023, the Japan Society of Pain Clinicians (JSPC) issued this consensus statement on chronic pain treatment in cancer survivors. With recent advances in the early diagnosis and treatment of cancer, its prognosis has improved, so prolonged pain in cancer survivors is considered to represent chronic pain and should be addressed. In this statement, we emphasize that not all cancer survivor pain is cancer pain.

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Article Synopsis
  • Liquid biopsy (LB) is a minimally invasive method for analyzing tumor-derived materials, and this study explores the potential of bile as a superior source of cell-free DNA (cfDNA) compared to plasma for detecting mutations in biliary tract cancers.
  • The research involved collecting cfDNA from the bile of 24 cancer cases, including various types of biliary tract cancers, and applying a multigene panel to identify cancer driver mutations.
  • Results indicated that bile yielded a higher detection rate of cancer driver mutations, with 54% of bile samples testing positive compared to just 17% of plasma samples, highlighting bile's effectiveness for liquid biopsy analysis.
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