Publications by authors named "M Irino"

Serologic RhD-negative red cells can cause anti-D alloimmunization if they carry the Asian-type DEL or other DEL variants. genotyping is a viable countermeasure if available, but inexpensive alternatives are worthy of consideration. RhD-negative blood donors in Japan were studied by anti-D adsorption-elution and genotyping.

View Article and Find Full Text PDF

In a series of inbred Senescence-Accelerated mice (SAM) strains, accelerated-senescence prone SAMP substrains show early onset and rapid advancement of senescence. SAMP8 and SAMP10, in particular, exhibit a significant age-related deterioration in memory and learning for passive and active avoidance tasks with, respectively, a low and high incidence of systemic senile amyloidosis. In the brains of both SAMP8 and SAMP10 strains, we have found numerous morphological alterations.

View Article and Find Full Text PDF

The distribution of immunoreactive catecholamine neurons and fibers was investigated in brindled mottled mouse, a murine model of Kinky hair syndrome (KHS), using antisera against tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH). In all mice, including normal littermate controls, a transient increase of TH-immunoreactive neurons (TH-IN) was observed in the cerebral cortex during the second postnatal week. The numbers of TH-IN were more pronounced in hemizygous brindled males (MObr/y).

View Article and Find Full Text PDF

The brindled mottled mutant mouse, a model of Menkes' disease, has alterations in copper homeostasis which cause, among other sequelae, neuronal degeneration in selected areas of brain. This work examined the neurochemical changes at postnatal days (PND) 15, 30 and 60 in females heterozygous for the sex-linked brindled mutation. These data were compared to behavioral alterations and to fur coat color at these same time points.

View Article and Find Full Text PDF

Schwann cells were isolated and cultured from the twitcher mouse, an authentic model of human globoid cell leukodystrophy. We observed some difference in morphology and initial cell growth between the cells from suckling and adult mice. Initial growth was slower in homozygous and heterozygous twitcher (twi/twi; twi/+) cells than in normal cells (+/+) when cells were cultured from suckling mice.

View Article and Find Full Text PDF