The moderating effects of physical activity on social anxiety and sleep disturbance: managing gaming disorder in young e-sports players.

Background: Internet Gaming Disorder (IGD) has emerged as an increasing public health concern, particularly among adolescent and young e-sports players in recent years. The immersive and competitive nature of online gaming has been associated with an increase in mental health issues such as anxiety and insomnia among individuals with IGD. This study aims to examine the potential relationship between IGD, social anxiety, and insomnia, investigate the mediating role of social anxiety in this relationship, and explore the moderating role of physical activity in alleviating the negative effects of IGD.

Effects of lupeol on experimental testicular ischemiareperfusion damage in rats.

Background: Infertility and organ loss are possible outcomes of testicular torsion, a urological emergency. This study aimed to demonstrate the impact of lupeol on testicular ischemia/reperfusion damage.

Methods: Thirty adult male Spraque-Dawley rats were randomized into five groups: Control (C), Lupeol (L), Ischemia (Isc), Treatment 1 (T1), and Treatment 2 (T2).

Effects of Lupeol on Intestinal Anastomosis After Experimental Intestinal Ischemia-Reperfusion Injury in Rats.

Background: Intestinal ischemia/reperfusion (I/R) injury can occur in a wide variety of diseases and surgeries. If necessary, the blood flow should be restored, including re-anastomosis by removing the intestines with impaired circulation. In this process, anastomotic strength is as important as inflammatory responses and oxidative stress.

Development of a Recombinant Omicron BA.1 Subunit Vaccine Candidate in Pichia pastoris.

Low-cost and safe vaccines are needed to fill the vaccine inequity gap for future pandemics. Pichia pastoris is an ideal expression system for recombinant protein production due to its cost-effective and easy-to-scale-up process. Here, we developed a next-generation SARS-CoV2 Omicron BA.

A New Perspective on the Management of Primary Immunodeficiencies: Evaluation of Arrhythmia and Cardiac Diseases.

Introduction: Primary immunodeficiency diseases (PIDs) are a growing group of rarely seen diseases. Various clinical conditions like autoimmunity, lymphoproliferative/malignant diseases, chronic lung, and gastrointestinal system diseases have been identified which accompanies PIDs besides recurrent infections. However, there is a lack of information about accompanying cardiovascular diseases.