Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women.

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants of clonal expansion remain poorly understood. We performed sequencing at >4,000x depth of coverage for CHIP mutations in 6,986 postmenopausal women from the Women's Health Initiative at two timepoints approximately 15 years apart. Among 3,685 mutations detected at baseline (VAF ≥ 0.

Experience-based food insecurity in Bangladesh: Evidence from Household Income and Expenditure Survey 2022.

This paper examines the current state of food insecurity in Bangladesh and its socio-economic drivers using data from the latest Household Income and Expenditure Survey (HIES 2022). Unlike previous studies that relied on less precise measures of food insecurity, such as food expenditure, diversity, and calorie intake, this study employs the internationally recognized Food Insecurity Experience Scale (FIES) and Rasch model-based thresholds to classify households as food secure or insecure. Multilevel logistic regression is used to identify significant predictors of moderate and severe food insecurity, considering the hierarchical structure of the data, with households nested within geographical clusters.

Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes.

Background: Significant progress has been made in elucidating the genetic underpinnings of Autism Spectrum Disorder (ASD). However, there are still significant gaps in our understanding of the link between genomics, neurobiology and clinical phenotype in scientific discovery. New models are therefore needed to address these gaps.

Investigating the impact of oligo-chitosan on the growth dynamics and yield traits of L. 'BRRI dhan29' under subtropical conditions.

Reducing the harmful chemical use along with obtaining potential yield in field is a worth exploring practice in rice cultivation. To mitigate the prevailing yield gap, the current study was designed to evaluate the effect of chitosan in improving growth, yield contributing characters and yield of rice. The experiment comprised eight different treatments control (no fertilizer and Chitosan) (T), conventional method (with fertilizers) (T), conventional method with foliar spray of 100 ppm chitosan solution (T), conventional method with foliar spray of 300 ppm chitosan solution (T), conventional method with foliar spray of 500 ppm chitosan solution (T), only foliar spray of 100 ppm chitosan solution (T), only foliar spray of 300 ppm chitosan solution (T), and only foliar spray of 500 ppm chitosan solution (T).

The proper application of logistic regression model in complex survey data: a systematic review.

Background: Logistic regression is a useful statistical technique commonly used in many fields like healthcare, marketing, or finance to generate insights from binary outcomes (e.g., sick vs.