Antibody dependent cellular cytotoxicity (ADCC)-reaction and an in vitro steroid sensitivity test of peripheral lymphocytes in children with malignant haematological and autoimmune diseases.

ADCC reaction (antibody dependent cellular cytotoxicity), ADCC capacity and ADCC steroid sensitivity examinations were performed in 20 children with tumorous or haematological diseases, 10 children with autoimmune diseases, and appropriate controls, in order to establish the killer function and steroid sensitivity. In the above diseases a study was also made of the correlation of the individual reactions with the duration of steroid therapy. The two patient groups did not exhibit a significant difference from the controls as concerns the ADCC reaction and ADCC capacity.

Leukocyte beta-glucosidase in a child with Gaucher's disease and his kinship.

Beta-glucosidase was determined in leukocyte homogenates of a male child with Gaucher's disease and members of his family. An important difference in enzyme activity was found in the heterozygous gene carriers; in one obligate heterozygote, the mother, a high residual enzyme capacity was detected. Various methods of enzyme determination using various substrates are recommended for the detection of the gene carrier condition.