Publications by authors named "M Ihara"
Pharmaceutical discharge to the environment is of concern due to its potential adverse effects on aquatic species. It is estimated that around 40% of pharmaceuticals target G protein-coupled receptors (GPCRs). The transforming growth factor- (TGF) shedding assay was applied to measure the antagonistic activities of pharmaceuticals against human GPCRs.
View Article and Find Full Text PDFAims: Atherogenic dyslipidemia (AD) is regarded as a residual risk of cardiovascular diseases characterized by low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels and related to the intracranial stenosis of atheromatous thrombotic brain infarction (ATBI). Further, atherosclerosis is possibly related to another stroke subtype, including cryptogenic stroke (CS). In particular, an aortic complicated lesion (ACL) is a notable embolic source of CS, since recurrence of aortogenic brain embolism is not rare.
View Article and Find Full Text PDFArticle Synopsis
- - Post-stroke complications like epilepsy and cognitive impairment are on the rise due to an aging population, with post-stroke epilepsy making up about half of epilepsy cases in older adults, highlighting the need for effective seizure management.
- - Research is advancing in areas such as diagnostic techniques and preventative strategies for post-stroke epilepsy while also emphasizing the importance of controlling vascular risk factors to potentially prevent conditions like vascular dementia and Alzheimer's.
- - The review provides essential clinical information, including diagnostic criteria, classification, risk factors, measurements, and treatment options for managing complications that arise post-stroke.
Oral health is fundamentally linked to systemic health, with dental caries and periodontal diseases playing critical roles in the overall well-being. In Japan, a concerted effort to enhance oral health through a comprehensive initiative that started in 2024 emphasizes the prevention of oral diseases by fostering closer collaboration between medical and dental care providers. This initiative acknowledges the intricate connection between oral health and systemic conditions, including metabolic disorders and cerebrovascular and cardiovascular diseases.
View Article and Find Full Text PDFBackground: Adrenomedullin has angiogenic and vasoprotective effects in acute ischemic stroke (AIS). This investigator-initiated trial aimed to evaluate the safety, efficacy, and optimal administration of adrenomedullin in treating AIS.
Methods: In this single-center, multi-cohort, double-blinded, randomized, placebo-controlled, Phase II trial, patients with AIS received pulsed adrenomedullin (9 ng/kg/min for 8 h daily over 7 days) or placebo in the first-half cohort, and continuous-pulsed adrenomedullin (9 ng/kg/min for 72 h during the first 3 days and 8 h daily between Day 4-7) or placebo in the second-half cohort.