Publications by authors named "M Ignacio"
We previously reported that mice immunized twice with a lipid nanoparticle vaccine comprising four monkeypox viral mRNAs raised neutralizing antibodies and antigen-specific T cells and were protected against a lethal intranasal challenge with vaccinia virus (VACV). Here we demonstrated that the mRNA vaccine also protects mice against intranasal and intraperitoneal infections with monkeypox virus and bioluminescence imaging showed that vaccination greatly reduces or prevents VACV replication and spread from intranasal, rectal, and dermal inoculation sites. A single vaccination provided considerable protection that was enhanced by boosting for at least 4 months.
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- * The study demonstrated that mice vaccinated with this new quadrivalent lipid nanoparticle vaccine not only developed protective immune responses but also significantly reduced virus spread in their bodies after exposure.
- * Findings indicate that even a single dose of the vaccine offers considerable protection, which can be enhanced with a booster, suggesting strong potential for mRNA vaccines in preventing orthopoxvirus infections and warranting further clinical testing.
Rhinovirus C (RV-C) infects airway epithelial cells and is an important cause of acute respiratory disease in humans. To interrogate the mechanisms of RV-C-mediated disease, animal models are essential. Towards this, RV-C infection was recently reported in wild-type (WT) mice, yet, titers were not sustained.
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- The study investigates the awareness and experiences of Long COVID among African American/Black, Hispanic/Latino, and Indigenous adults in Arizona who tested positive for COVID-19.
- Participants showed limited awareness of Long COVID but reported experiencing symptoms such as brain fog and fatigue, alongside mental health challenges like anxiety.
- The researchers emphasize the need for better access to culturally relevant information and health resources to address Long COVID disparities in these communities.
Objective: To describe the possibility of applying Fuzzy Logic in analyzing the vulnerability of Women Who Have Sex with Women to Sexually Transmitted Infections/HIV/AIDS.
Methods: We developed a Fuzzy Logic system with 17 input variables and one output variable, using data related to vulnerability in a municipality located in the Midwest region of the State of São Paulo, Brazil.
Results: The factor with the greatest positive impact was the confirmation that a low understanding of Sexually Transmitted Infections/HIV/AIDS is associated with higher vulnerability.