Publications by authors named "M Iacovone"

Article Synopsis
  • ARID1A is a protein that is often changed in different types of cancer and helps fix DNA when it gets damaged.
  • When ARID1A is missing, it can cause problems with repairing DNA and lead to more issues in cells, like extra tiny nuclei.
  • ARID1A also affects how cells respond to treatments like radiation therapy, making it an important marker for doctors to understand how well a patient's cancer might respond to treatment.
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Protein analysis in biological fluids, such as urine, by means of mass spectrometry (MS) still suffers for insufficient standardization in protocols for sample collection, storage and preparation. In this work, the influence of these variables on healthy donors human urine protein profiling performed by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was studied. A screening of various urine sample pre-treatment procedures and different sample deposition approaches on the MALDI target was performed.

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