Publications by authors named "M Iacob"
Introduction: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by significant autoantibodies, particularly targeting nuclear antigens. SLE pathogenesis involves genetic, environmental, and hormonal factors. The disease course includes flares and remission and involves various organs.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how altered endothelial flow sensitivity related to polycystin deficiency contributes to hypertension in autosomal dominant polycystic kidney disease (ADPKD) patients.
- Nineteen ADPKD patients were treated with the dopamine receptor agonist rotigotine, showing that a higher dose significantly improved nitric oxide release and endothelial function without major changes in overall blood pressure.
- The findings suggest that targeting endothelial dopamine receptors could be a promising new treatment strategy to mitigate cardiovascular issues linked with ADPKD.
Article Synopsis
- - Graves' disease (GD) is an autoimmune condition that impacts the thyroid, potentially leading to hyperthyroidism and other complications, but recent studies indicate it may also increase the risk of thyroid cancer, especially differentiated thyroid carcinomas and, less frequently, medullary thyroid carcinoma (MTC).
- - A case series highlighted three female patients with GD who were diagnosed with MTC, all showing concerning thyroid nodules and elevated calcitonin levels, ultimately requiring total thyroid removal, with histology confirming MTC.
- - The study emphasizes the need for routine calcitonin screening in GD patients to ensure early detection of thyroid cancers and recommends this testing be included in standard diagnostic procedures for those with thyroid abnormalities.
The aim of this study was to evaluate the clinical-pathological profile in young patients with thyroid cancer. We realized a retrospective study on patients with thyroid neoplasms who underwent surgery at the "Pius Brinzeu" County Clinical Emergency Hospital in Timisoara, Romania. A comparative analysis of some parameters between two groups, young patients (<45 years) versus patients ≥45 years, was performed.
View Article and Find Full Text PDF