[The effect of treatment on interleukin-1beta production in patients with first episode of juvenile psychosis].

Fifty-six patients (mean age 21,5+/-0,4 years) with first episode of endogenous psychosis (ICD-10 diagnosis F20.0, F20.2, F25) were studied before and after 4 and 8 weeks of the treatment with haloperidol and clozapine.

[The relationship between clinical changes in schizophrenia, acoustic evoked potentials, and background electroencephalogram].

The study was made of relationship between the dynamics of neurophysiological parameters and the changes of clinical state assessed by the PANSS and the CGI in 17 male patients with schizophrenia. Significant correlations between the reduction of psychopathological symptoms by PANSS and an increase of P300 amplitude and spectral density of background EEG in delta-, theta-, alpha 1- and alpha 3-ranges and the reduction of psychotic symptoms by CGI and an increase density in delta-, theta-, alpha 1-diapasons were found. The findings are considered as the evidence of correlations between an improvement of clinical state and "normalization" of different processes of attention, thinking and memory reflected changes of the tested EEG parameters.

[The changes of the function of lymphocytes natural killers in schizophrenics].

Cytotoxic activity and lymphocyte natural killers (NK) number as well as gamma-interferon (gamma-IFN) production were studied in patients with paranoid (22 patients) and progressive attack-like (39 patients) schizophrenia (47 male and 14 female patients aged 16-62 years). Compared to controls, a decrease of NK activity and a trend towards gamma-IFN production decrease were found. In the patients, NK lymphocytes number was not changed.

[Auditory evoked potentials in patients with schizophrenia and affective disorders].

Eighteen patients with schizophrenia and 18 patients with affective disorders (depression) underwent regisTration of auditory event-related potentials (ERPs) recording in oddball paradigm. All the patients were in remission. In both groups of the patients, the N100 ERPs amplitudes to non-target stimuli were significantly smaller and N200 and P300 latencies were longer than in 18 normals.