Publications by authors named "M Ia MELAMUD"
Patients with systemic lupus erythematosus (SLE) are known to frequently suffer from comorbid cardiovascular diseases (CVDs). There are abundant data on cytokine levels and their role in the pathogenesis of SLE, while growth factors have received much less attention. The aim of this study was to analyze growth factor levels in SLE patients and their association with the presence of comorbid CVDs.
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- Delirium Tremens (DT) is a severe complication of alcohol withdrawal syndrome (AWS), linked to neurotransmitter issues, inflammation, and increased bodily permeability, but its biomarkers are not well understood.
- The study compared healthy individuals and two AWS patient groups (with and without DT) to analyze various biomarkers, finding significant changes in certain biochemical markers and elevated inflammatory indicators in DT patients.
- Results suggested a subgroup of AWS patients exhibited high inflammation, indicating the complexity of patient profiles in AWS and highlighting the need for further research into specific biomarkers related to DT.
Multiple lines of evidence are known to confirm the pro-inflammatory state of some patients with schizophrenia and the involvement of inflammatory mechanisms in the pathogenesis of psychosis. The concentration of peripheral biomarkers is associated with the severity of inflammation and can be used for patient stratification. Here, we analyzed changes in serum concentrations of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-10, IL-21, APRIL, BAFF, PBEF/Visfatin, IFN-α, and TNF-α) and growth/neurotrophic factors (GM-CSF, NRG1-β1, NGF-β, and GDNF) in patients with schizophrenia in an exacerbation phase.
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- The study examines levels of cell-free DNA (cfDNA) in severe psychiatric disorders like schizophrenia, bipolar disorder (BD), and depressive disorders (DDs) compared to healthy individuals.
- It finds that individuals with schizophrenia have significantly higher levels of total cfDNA and genomic cfDNA (cf-gDNA) than healthy donors, suggesting a link to chronic systemic inflammation.
- However, it finds no significant differences in mitochondrial cfDNA (cf-mtDNA) levels in BD and DDs, indicating the need for more research due to varying sample sizes and data inconsistencies.
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- * In this research, multiplex immunoassays were used to analyze 41 cytokines in SLE and MS patients against healthy donors, revealing increased levels of 11 cytokines in SLE, while MS showed decreased levels of 10 cytokines.
- * The study found significant differences in cytokine levels between SLE and MS, highlighting disrupted functional relationships within cytokine networks in both conditions, which may improve our understanding of their pathogenesis.