This paper discusses the potential pathogenetic mechanisms by which the damaging action of hyperhomocysteinemia on the vessels is realized, namely a negative effect on the structure and function of the vessel wall, on proliferation of smooth muscle cells and endothelium-dependent vasodilatation; on the processes of blood cell interaction with the vessel wall (adhesion of monocytes, platelet adhesion and aggregation, etc): prothrombogenic action on the coagulation system, and effect of homocysteine on adenosine concentration in plasma and tissues.
View Article and Find Full Text PDFTwo families of gene transcription factors - these review deals with peroxisome proliferator activated receptors (PP AR) and nuclear factor kappa B (NFkappaB). PPAR family controls lipid metabolism, processes of inflammation and atherothrombosis. Activation of NFkappaB initiates transcription of genes of such proinflammatory factors as cytokines, chemokines and adhesion molecules.
View Article and Find Full Text PDFMR-tomography was compared to echocardiography for efficacy in diagnosis of left ventricular hypertrophy in 55 patients with stage II essential (WHO criteria). Left ventricular myocardial mass estimated at echocardiography appeared significantly greater than this mass estimated at MR tomography: 244.0 +/- 9.
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